WatCH License Agreement This License agreement with MSU covers your use of the WatCH software developed in the Protein Structural Analysis and Design Lab at MSU by Paul C. Sanschagrin and Leslie A. Kuhn, Dept. of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824; (517) 353-8745 (e-mail: kuhnl@msu.edu) 1. Description of Product. As used in this agreement, "Product" means the full, integrated Version 1 of the "WatCH" software for analyzing conservation of water sites in related protein structures, and any associated documentation, developed by Michigan State University personnel and copyrighted by the Michigan State University Board of Trustees. 2. License. MSU grants to you a non-exclusive, perpetual, non-transferable license to use the Product for your internal purposes on site. You may develop derivatives of the Product for internal use, provided MSU copyright notices remain intact and that the contributions of MSU personnel as outlined in (3) are included. You may make copies of the software as needed for your internal purposes, provided MSU copyright notices remain intact and the contributions of MSU personnel outlined in (3) are included. Neither the Product, Product copies, or derivatives from the Product may be transferred, licensed, or sold. 3. Acknowledgements. You agree to acknowledge the use of WatCH in publications or presentations by citing the following reference: P. C. Sanschagrin and L. A. Kuhn (1998) "Cluster Analysis of Consensus Water Sites in Thrombin and Trypsin Shows Conservation Between Serine Proteases and Contributions to Ligand Specificity", Protein Science 7, 2054-2064. 4. Prohibited Uses of the Product. You may not make copies of the Product which do not contain the notifications of copyright exactly as provided in the Product supplied to you by MSU. You may not transfer or assign your rights under this License without the prior express written consent of MSU. 5. Prohibited Uses of the University Name and Marks. You agree to not use the MSU name or marks in publicity, advertising, fund-raising, or similar activities without the prior written approval of MSU. 6. Intellectual Property. Michigan State University retains title to Product. You agree to use reasonable efforts to protect the Product from unauthorized use or reproduction. All rights not specifically granted in this License are reserved by MSU. 7. Warranty. MSU MAKES NO OTHER WARRANTY, EXPRESS OR IMPLIED, TO YOU OR ANY OTHER PERSON OR ENTITY. SPECIFICALLY, MSU MAKES NO WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OF PRODUCT. MSU WILL NOT BE LIABLE FOR SPECIAL, INCIDENTAL, CONSEQUENTIAL, INDIRECT OR OTHER SIMILAR DAMAGES, EVEN IF MSU OR ITS EMPLOYEES HAVE BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES. IN NO EVENT WILL MSU LIABILITY FOR ANY DAMAGES TO YOU OR ANY PERSON EVER EXCEED ANY FEE PAID FOR THE LICENSE TO USE THE PRODUCT, REGARDLESS OF ANY FORM OF THE CLAIM. Additional statements by employees of MSU, such as correspondence or oral presentations, do not constitute warranties by MSU and should not be relied upon. 8. Supplementary Provisions. This License represents the entire understanding and agreement between MSU and you regarding the Product, and supersedes any prior purchase order, communications, advertising, or representations. This License may be modified only in a written amendment signed by an authorized MSU officer. If any provision of this License shall be unlawful, void, or for any reason unenforceable, it shall be deemed severable from, and shall in no way affect the validity or enforceability of the remaining provision of this agreement. This License shall be governed by Michigan law. 9. Termination. In the event that either party hereto commits any breach of or default in any of the terms or conditions of this Agreement, and also shall fail to remedy such default or breach within ninety (90) days after receipt of written notice of such breach or default, the party giving notice may at its option and in addition to any other remedies which it may have by law, terminate this Agreement by sending notice of termination in writing to the other party. Such termination shall be effective as of the date of the receipt of such notice.